What Is Happening to Your Bones

Bone is living tissue in a constant state of remodeling — old bone is broken down (resorption) by cells called osteoclasts, and new bone is built (formation) by cells called osteoblasts. In healthy young adults, formation keeps pace with resorption, maintaining bone density. After roughly age 30 to 35, when peak bone mass is reached, resorption gradually begins to outpace formation. You lose roughly 0.5 to 1 percent of bone density per year from that point forward.

In women, menopause accelerates this dramatically. Estrogen is a powerful protector of bone — it suppresses osteoclast activity and promotes osteoblast function. When estrogen drops during menopause, bone resorption accelerates sharply. Women can lose 2 to 3 percent of bone density per year during the 5 to 7 years following menopause — a cumulative loss of 10 to 20 percent during this window. This is why osteoporosis disproportionately affects postmenopausal women.

The bone loss is silent. You cannot feel your bones thinning. There is no pain, no symptom, no warning — until a fracture occurs. A study in the Archives of Internal Medicine found that two-thirds of vertebral fractures (spine compression fractures) go undiagnosed because they cause only mild back pain that patients attribute to aging or muscle strain. Over time, multiple vertebral fractures cause the hunched posture (kyphosis) and height loss that people associate with aging — but this is not normal aging. It is untreated osteoporosis.

A 68-year-old retired teacher sneezed forcefully and felt a sharp pain in her mid-back. An X-ray revealed two compression fractures in her thoracic spine. A bone density scan showed severe osteoporosis with a T-score of -3.2. She had never been screened. "I thought osteoporosis was something that happened to other people," she said. "I was active, I ate well. But nobody told me that without estrogen after menopause, even that was not enough."

Risk Factors — Many Are Modifiable

Non-modifiable: Female sex (4 times higher risk than men). Age over 50. Menopause (especially early menopause before 45). Family history of osteoporosis or hip fracture. Small, thin body frame. White and Asian ethnicity (higher risk than Black and Hispanic populations, though osteoporosis affects all ethnicities).

Modifiable: Low calcium and vitamin D intake — the building materials for bone. Physical inactivity — bone strengthens in response to mechanical stress (weight-bearing and resistance exercise). Low protein intake — protein makes up roughly 50 percent of bone volume. Smoking — directly toxic to osteoblasts and accelerates estrogen metabolism. Excessive alcohol — more than 2 drinks daily impairs bone formation. Low body weight (BMI under 20) — less mechanical loading on bones.

Medical conditions and medications: Long-term corticosteroid use (prednisone) is the most common medication cause — it directly suppresses bone formation. Hyperthyroidism, hyperparathyroidism, celiac disease (malabsorption of calcium), rheumatoid arthritis, type 1 diabetes, and eating disorders all increase risk. Proton pump inhibitors used long-term may reduce calcium absorption.

A study in the Journal of Bone and Mineral Research quantified the impact: a 10 percent decrease in bone density at the hip doubles the risk of hip fracture. Small reductions in bone density translate to large increases in fracture risk.

Diagnosis — The DEXA Scan

Bone density is measured by dual-energy X-ray absorptiometry (DEXA scan) — a painless, noninvasive test that takes about 15 minutes. The scan measures bone mineral density at the hip and spine and compares your result to the peak bone mass of a healthy 30-year-old. The comparison is reported as a T-score.

T-score above -1.0: Normal bone density. T-score between -1.0 and -2.5: Osteopenia (low bone density). Not yet osteoporosis but bone is thinning and fracture risk is increasing. T-score at -2.5 or below: Osteoporosis. Fracture risk is significantly elevated. T-score at -2.5 or below with a fracture: Severe (established) osteoporosis.

Who should be screened: All women at age 65. All men at age 70. Postmenopausal women under 65 with risk factors. Anyone who fractures a bone from minimal trauma (a fall from standing height or less). Anyone on long-term corticosteroids. Earlier screening is warranted for those with multiple risk factors.

A critical gap: a study in the Archives of Internal Medicine found that fewer than 25 percent of women who fracture a bone receive a bone density test or osteoporosis treatment within the following year. The fracture itself is treated, but the disease causing it is ignored. If you break a bone after age 50 from a simple fall, insist on a DEXA scan.

Treatment and Prevention — Building and Protecting Bone

Calcium: 1,000mg daily for adults under 50 and men under 70. 1,200mg for women over 50 and men over 70. Food sources are preferred over supplements — dairy, fortified plant milks, canned sardines with bones, tofu, leafy greens (kale, broccoli — not spinach, which blocks absorption). If dietary intake is insufficient, calcium citrate supplements are better absorbed than calcium carbonate, especially in older adults with reduced stomach acid.

Vitamin D: Essential for calcium absorption. 600 to 800 IU daily (some experts recommend 1,000 to 2,000 IU, particularly for those with low levels). A study in the New England Journal of Medicine found that vitamin D combined with calcium reduced hip fracture risk by 30 percent in institutionalized elderly women.

Exercise: Weight-bearing exercise (walking, jogging, dancing, stair climbing) and resistance training (weights, resistance bands) directly stimulate bone formation through mechanical loading. A meta-analysis in the Journal of Bone and Mineral Research found that combined weight-bearing and resistance exercise increased lumbar spine bone density by 1 to 2 percent over 12 months. This may sound small, but it reverses the direction from losing 1 percent per year to gaining 1 percent — a net 2 percent annual improvement. Balance exercises (tai chi, yoga) reduce fall risk by 23 to 49 percent according to a Cochrane review — preventing the fall prevents the fracture.

Medications for osteoporosis: Bisphosphonates (alendronate, risedronate, zoledronic acid) are first-line. They inhibit osteoclasts, slowing bone resorption. Alendronate reduces hip fracture risk by 50 percent according to the FIT trial. Taken weekly (oral) or annually (IV zoledronic acid). Denosumab (Prolia) is a biologic injection every 6 months that blocks osteoclast formation — reduces vertebral fractures by 68 percent. Romosozumab (Evenity) is a newer anabolic agent that both builds new bone and reduces resorption — the ARCH trial found it reduced vertebral fractures by 73 percent compared to alendronate. Hormone replacement therapy protects bone but is typically used for menopausal symptoms rather than osteoporosis specifically.

Fall prevention: Since most osteoporotic fractures result from falls, preventing falls is as important as treating bone density. Remove home hazards (loose rugs, poor lighting, clutter). Install grab bars in bathrooms. Review medications that cause dizziness (sedatives, blood pressure medications). Check vision annually. A study in the New England Journal of Medicine found that a comprehensive fall prevention program reduced falls by 30 percent in community-dwelling older adults.